Filipino-American guitarist and composer. Active since 1986, Santiago is best known as the lead guitarist for the American alternative rock band the Pixies. After the band's breakup in 1993, Santiago produced musical scores for film and television documentaries, and he formed The Martinis with his wife, Linda Mallari. He also contributed to albums by Charles Douglas and former Pixies band-mate Frank Black. Santiago resumed his role as the Pixies' lead guitarist when they reunited in 2004.